Clomiphene is primarily an oral synthetic chemical that binds to estrogen receptors found in the brain and which causes an increase in FSH. In this article, we offer you well-researched information regarding the efficacy of Clomiphene in treating infertility, how it works, and the potential side effects.
Studies have shown that 70 percent of females who have difficulties ovulating every month will produce an egg when subjected to Clomiphene. However, this will also depend on the age of the patient. For example, female below the age of 35 years have 20-25% rate of achieving pregnancy (considering that no other significant factors prevail). Older counterparts may not make this rate because they have low egg quality. The success rates are individual and will depend on several factors. Clomiphene, formerly known as Clomid, was traditionally used as an off-label drug to treat infertility in men. Infertility remains one of the issues that many men and women struggle with in life.
What is Clomiphene Citrate?
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In some instances, a doctor may prescribe this drug to treat male infertility. It is an ovary stimulant popularly prescribed by physicians to treat impotence in women. Its mechanism is similar to that of estrogens. This drug promotes the production of ovaries and the release of the egg from the ovaries for fertilization. Radically this enhances the chances of fertilization since it increases the chances of ovulation. The U.S. FDA (Food and Drug Administration) has approved the drug as an option for treating infertility in women. However, physicians and pharmacists also prescribe this medication for treating infertility in males.
Does Clomiphene Work in Men?
Studies have established that Clomiphene raises the levels of luteinizing hormone (LH) and follicle-stimulating hormones, all of which are critical in maintaining the fertility of both men and women. Luteinizing hormone is known to stimulate the production of testosterone hormones in men while FSH plays a crucial role in spermatogenesis, which increases the number of sperms. Although there is no rich scientific literature to conclusively support the claim that LH and FSH can impact male fertility, the current research points to the fact that it can increase productivity in men. Science has shown that the Clomiphene citrate can improve sperm motility (movement of sperm to cause fertilization of an egg) in men. However, some studies have indicated that this drug may reduce the sperm count in some users. That could be as a result of the dosage that one may be using.
The fact that the FDA is yet to admit Clomiphene citrate in treating male infertility, there is no established dosage for it. For this reason, users need to closely monitor their response to different dosages to establish the best dosage. Generally, some studies have suggested dosage of 12.5-400mg per day. A meta-analysis of three studies found that taking 50mg per day can help treat infertility.
When do doctors prescribe it for males?
Doctors can decide to prescribe a medication off-label if they think that the advantages outweigh the risks. Although the FDA has only allowed clomiphene citrate for the treatment of infertility in girls, physicians may also want to prescribe it for guys with unexplained impotence or when other methods have been ineffective or are unsuitable.
The doctor needs to explain - neither the safety nor the effectiveness of the drug for this purpose is fully known and to ensure that the person understands any potential risks.
Clomiphene citrate can cause numerous, albeit mild effects among users, including the following
Headaches and dizziness.
• Nausea and vomiting
• problems with vision
• stomach pain or discomfort
• mouth ulcers
• breast growth
• Flushing (ubiquitous),
• Increased ovulation and sensitivity (mittelschmerz),
• Blurred vision,
• Breast tenderness,
• Headache, and
• Vaginal dryness
If you feel any of the side effects persistently because of taking clomiphene citrate, seek the help of a doctor immediately. One of the suggestive solutions may be to reduce the dosage or stop the drug altogether. It is a good option for candidates who cannot use testosterone therapy. The fact that clomiphene citrate increases the number of testosterone hormones it can treat hypogonadism.