Cardarine (or GW-501516) was jointly designed by Ligand Pharmaceuticals and Glaxo Smith Kline, which are some of the leading pharmaceutical companies in the drug industry. Initially, the drug was developed and highly popularized for its potency in dealing with dyslipidemic disorders such as atherosclerosis. It is the most common factor behind numerous vascular diseases such as stroke, cardiac arrest, and heart attacks. After years of its use for the mentioned diseases, it was discovered in the athletic world to be a great drug for increasing endurance and adding strength. It is why it remains a popular chemical to date.
How Does GW 501516 Work?
Table of Contents
- 1 How Does GW 501516 Work?
- 2 Some of the additional benefits of Cardarine
- 3 GW501516: The Real Facts You Never Knew About It
- 4 WHAT IS GW1516?
- 5 Is GW501516 a SARM?
Cardarine falls in the class of PPAR (peroxisome proliferator-activated receptor) agonists that work almost in the same way SARMs work. They become active by joining to the androgen receptors of the bones and the muscles. Once they activate the receptors, they cause an increase in the number of amino acids and glucose absorption into the skeletal muscles. This process leads to increased insulin sensitivity in the body.
The increased absorption of amino acids into the bones and muscles enhances the synthesis of proteins. It, in turn, increases muscle growth and strength gains. By consuming this substance, our bodies will quickly and efficiently convert the carbohydrates and fat instead of storing them in their inactive forms. Subsequently, this will mean increased muscle mass and adequate energy for our physical exercises. Perhaps you need to know that the PPAR is a family of nuclear receptors that are used to trigger genetic pathways that are significant in the spending of energy. By so doing, the process of transfer of cholesterol is hastened, reducing the risk of accumulating the materials.
Cardarine also increases the amount of healthy cholesterol in the body by transporting it to the liver for purposes of being metabolized. It means increased energy and reduced risks of bad cholesterol in the body. It also promotes the proper functioning of the liver and helps the body to rid excess belly fat. Results are a dramatic reduction of triglyceride and the amount of glucose in the shape of the user.
Some of the additional benefits of Cardarine
The introduction of Cardarine is now considered one of the most phenomenal developments in the medical and sports fields, owing to its unparalleled solutions to many health and physical performance problems.
It has high bio-availability properties, meaning it is available in readily absorbable forms. It means even a small dose can yield the desired results.
2. Inhibits the Synthesis of Fatty Acids
It works by transferring pro-inflammatory mediators into the fat cells to help limit the process of lipogenesis (a gene activity that deals with the synthesis of fatty acid).
3. Non Stimulant
Cardarine is not a stimulant, which means that it does not come with euphoric effects when taken.
The drug has so far been found not to be harmful to the liver and other body organs. Therefore, users won't worry about the need for post-cycle therapy (PCT) to reduce the steroidal effects.
5. It is not Estrogenic
Cardarine has is not an active anabolic androgen compound so it won't have any effect on the natural production of testosterone hormones. It doesn't have any side effects such as hair loss, weight gain, or water retention.
6. Can be stacked
Most SARMs can be stacked with this compound, including endurance enhancing substances out there without having any adverse effect on the body.
GW501516: The Real Facts You Never Knew About It
GW-501516 or Cardarine is commonly known, is a popular compound that was first designed in the 90s. With a significant objective of preventing the development of tumors in various body organs such as the prostate, brain, colon, and breast tissues. While its main goal was addressing the said issues, the drug has gained immense popularity among bodybuilders as an incredibly strong SARM. The drug can burn excess fat, enhance endurance, and shorten the period needed for people to recover after a strenuous exercise.
What makes this compound even more popular is the fact that it doesn't have any severe side effects. If this small bit is anything to rely on, then Cardrine is the best thing that ever happened to the bodybuilders across the world. But what exactly does it deliver? Let's delve a bit into the factual truths you probably never knew and which could form the basis for your decision to buy or not to buy it.
WHAT IS GW1516?
A reputable pharmaceutical company, GlaxoSmithKline, designed the drug with the sole intention to treat problems around diabetes and heart complications. However, the development would later stop before its full realization when the specimen rats on which trials were being conducted started to show traits of cancer. However, similar trends and habits haven't shown up in human beings, an indicator that the condition could only be common on animals.
For many years, researchers have struggled to comprehend a suitable solution to lifestyle diseases such as diabetes, heart illnesses, and inflammation of the lungs. As a result, there has been an increased desire to find a compound that can enhance physical endurance while at the same time, increasing the ability of the body to burn extra fat. While on the journey to finding the right drug, researchers came to a surprising conclusion that Cardarine could be that unique compound. Capable of lending itself as the solution to the problems of endurance and diseases of the heart. They arrived at a PPAR-delta pathway and concluded that activation of this pathway could be a powerful treatment that people have been looking for to help deal with decreasing energy. It is one of the compounds that directly bind to the pathway found in the muscles and bones to facilitate the following:
- Improved muscle and tissue growth
- Enhanced heart health
- Increased metabolism
- Reduced inflammation
We can conclude that GW501516 is a promising compound.
Is GW501516 a SARM?
The answer is no! Cardarine is NOT a SARM. SARMs are compounds that bind to androgen receptors to increase muscle mass. Some SARMs have been designed to mimic the action of testosterone hormones. An excellent example of such compounds is the LGD-4033 and RAD-140.
On the contrary, the compound in question is a PPAR-delta pathway activator whose action is not by targeting the androgen receptors in ways the SARMs do. The PPAR-delta works by activating the fat-burning genes to cut down the number of fatty acids, VLDL proteins, and triglycerides. These findings have been corroborated with randomized clinical trials conducted to help determine its effect on reducing belly fat among human beings.
Users report a drastic reduction in the levels of HDL cholesterol in the body on using the compound. Also, users say it adds stamina and enhances muscle growth besides boosting endurance, especially during peak performance.
What's more, the compound is believed to increase and maintain blood flow to the brain, which prevents stress and damage to the brain cells. Also, PPAR activators have been found to the growth of nerve cells.